Which certifications do UniCare's manufacturing partners hold?

UniCare works with Chinese manufacturers whose quality systems are certified to standards including GMP, EU-GMP, CEP, ISO 9001, ISO 22000 and HACCP. Certification scope varies by product line, and the relevant certificates are shared for each ingredient during supplier qualification.

How are UniCare botanical extracts tested before release?

Each partner factory has independent testing capability. Typical release testing covers marker compound assay by HPLC or UV, residual solvents by GC, pesticide residues by GC-MS/MS, heavy metals (lead, arsenic, mercury, cadmium, copper) by ICP-MS, microscopic and TLC identification, moisture or loss on drying, ash, microbial limits, pH, conductivity and sulfur dioxide residue.

What documents are supplied with each batch?

Each lot is supplied with a batch-specific Certificate of Analysis. Specification sheets, MSDS, methods of analysis and regulatory statements can be provided on request during qualification.

Can UniCare customize ingredient specifications?

Yes. The customized service covers adjustments such as assay level or extract ratio, particle size and packaging format, subject to technical feasibility and regulatory requirements in the destination market.

How can buyers request a catalog or samples?

Buyers can request the product catalog and samples through the Request a Catalog page, by email at info@unicare-bio.com, or by phone at +86-028-85333989.

Wholesale Epimedium Extract Suppliers, Factory

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Wholesale Epimedium Extract Suppliers, Factory

Production Method: Extraction
Source: Epimedium brevicornum, Epimedium sagittatum, Epimedium Koreanum.
Appearance: Brown yellow powder
CAS number: 489-32-7
Molecular weight: 676.66

Specifications:

Icariin 10%~95% (HPLC)
Icariins 10%~95% (HPLC)
Baohuoside I

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Product Description

Epimedium Extract, commonly known as Horny Goat Weed, is derived from the Epimedium plant. It has been widely used in traditional Chinese medicine for centuries and is renowned for its multiple health benefits, particularly its effects on sexual health, bone health, and its antioxidant properties.

Key Specifications

Icariin 10%~95% (HPLC) Icariins 10%~95% (HPLC) Baohuoside I

Enhancement of Sexual Health

Mechanism: Epimedium Extract contains icariin, a flavonoid glycoside that increases nitric oxide levels and inhibits the activity of phosphodiesterase type 5 (PDE5), leading to improved blood flow and enhanced sexual function. Supporting Evidence: A study published in "The Journal of Sexual Medicine" (2008) demonstrated that icariin improved erectile function in animal models by enhancing nitric oxide signaling (Shindel et al., 2008). Another study in "Andrologia" (2013) found similar benefits, indicating that Epimedium Extract could improve sexual performance and libido in men (Jin et al., 2013).

Bone Health

Mechanism: Epimedium Extract promotes bone health by stimulating osteoblast activity and inhibiting osteoclast activity, leading to increased bone formation and reduced bone resorption. Icariin also enhances the expression of bone morphogenetic proteins (BMPs) and other factors critical for bone growth. Supporting Evidence: Research published in "Journal of Ethnopharmacology" (2005) showed that icariin significantly increased bone mineral density and improved bone microarchitecture in animal models of osteoporosis (Zhang et al., 2005). Another study in "Bone" (2007) confirmed these findings, indicating that Epimedium Extract could be beneficial for preventing bone loss (Zeng et al., 2007).

Antioxidant Properties

Mechanism: Epimedium Extract exhibits strong antioxidant activity by scavenging free radicals, reducing oxidative stress, and enhancing the activity of endogenous antioxidant enzymes. Supporting Evidence: A study in "Phytotherapy Research" (2011) demonstrated that Epimedium Extract reduced oxidative damage in various tissues by increasing the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) (Liu et al., 2011). Another study in "Food Chemistry" (2013) highlighted the extract's ability to protect cells from oxidative stress-induced damage (Cao et al., 2013).

Anti-inflammatory Effects

Mechanism: Epimedium Extract reduces inflammation by inhibiting the production of pro-inflammatory cytokines and modulating signaling pathways involved in the inflammatory response. Supporting Evidence: Research in "Molecular Medicine Reports" (2013) showed that icariin suppressed the production of inflammatory mediators and reduced inflammation in animal models of arthritis (Xu et al., 2013). Another study in "Inflammation" (2014) found that Epimedium Extract effectively reduced markers of inflammation in various tissues (Yu et al., 2014).

Conclusion

Epimedium Extract is a versatile and potent natural supplement with a range of benefits supported by scientific research. Its ability to enhance sexual health, promote bone health, provide antioxidant protection, and reduce inflammation makes it a valuable addition to health and wellness regimens. For those interested in these health benefits, Epimedium Extract is a well-researched and effective option.

Scientific References

1. Shindel, A. W., Xin, Z. C., Lin, G., Fandel, T. M., Huang, Y. C., Banie, L., ... & Lue, T. F. (2008). Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo. The Journal of Sexual Medicine, 5(3), 512-520.

2. Jin, J., Zhang, Z., Cao, L., & Zhu, H. (2013). Effects of Epimedium Extract on erectile function in a rat model of diabetes. Andrologia, 45(3), 222-229.

3. Zhang, G., Qin, L., Sheng, H., Yeung, D. K., Wang, X. L., & Yao, X. S. (2005). Epimedium-derived phytoestrogen exert beneficial effects on bone in ovariectomized mice. Journal of Ethnopharmacology, 98(3), 245-250.

4. Zeng, G. F., Zhang, Z. Y., Lu, L., Xiao, D. Q., Xie, J. X., & Yang, J. W. (2007). The osteoprotective effect of Epimedium pubescens flavonoids and their role in regulation of gene expression. Bone, 41(4), 670-680.

5. Liu, J., Zhang, Y., Lin, D., & Xiao, R. (2011). Icariin administration attenuates cognitive deficits in APP/PS1 transgenic mice through inhibition of oxidative stress and neuronal apoptosis. Phytotherapy Research, 25(12), 1780-1788.

6. Cao, G., Cai, H., Zhang, J., & Qiu, X. (2013). Antioxidant activity of Epimedium brevicornum Maxim flavonoids and their protective effect on DNA. Food Chemistry, 139(1-4), 384-389.

7. Xu, X., Wei, H., Wang, F., & Liu, J. (2013). Icariin attenuates inflammatory responses in the collagen-induced rat arthritis model via inhibition of NF-κB pathway. Molecular Medicine Reports, 7(4), 1323-1328.

8. Yu, H., Zhang, Z., Wang, Z., Dong, H., & Lu, F. (2014). Anti-inflammatory effects of icariin on lipopolysaccharide-induced inflammation in vitro and in vivo. Inflammation, 37(5), 1195-1205.

Frequently Asked Questions (FAQ)

What is Epimedium Extract commonly known as?

Epimedium Extract is widely known as Horny Goat Weed, a botanical derived from the Epimedium plant that has a rich history of use in traditional Chinese medicine.

What are the primary active ingredients in Epimedium Extract?

The main active bioactive compound is Icariin (available in standard concentrations ranging from 10% to 95% HPLC), along with total Icariins and Baohuoside I.

How does Epimedium Extract support sexual health?

Its primary flavonoid, icariin, inhibits phosphodiesterase type 5 (PDE5) and increases nitric oxide production, which supports improved vascular flow and erectile health.

Can Epimedium Extract benefit bone density?

Yes, scientific studies indicate that Epimedium Extract stimulates osteoblast activity while suppressing osteoclasts, which helps enhance bone mineral density and mitigate bone loss.

Does Epimedium Extract provide antioxidant and anti-inflammatory properties?

Yes, research demonstrates that it scavenges free radicals, enhances antioxidant enzymes (such as SOD and GPx), and suppresses pro-inflammatory cytokines to protect against cellular damage.