Which certifications do UniCare's manufacturing partners hold?

UniCare works with Chinese manufacturers whose quality systems are certified to standards including GMP, EU-GMP, CEP, ISO 9001, ISO 22000 and HACCP. Certification scope varies by product line, and the relevant certificates are shared for each ingredient during supplier qualification.

How are UniCare botanical extracts tested before release?

Each partner factory has independent testing capability. Typical release testing covers marker compound assay by HPLC or UV, residual solvents by GC, pesticide residues by GC-MS/MS, heavy metals (lead, arsenic, mercury, cadmium, copper) by ICP-MS, microscopic and TLC identification, moisture or loss on drying, ash, microbial limits, pH, conductivity and sulfur dioxide residue.

What documents are supplied with each batch?

Each lot is supplied with a batch-specific Certificate of Analysis. Specification sheets, MSDS, methods of analysis and regulatory statements can be provided on request during qualification.

Can UniCare customize ingredient specifications?

Yes. The customized service covers adjustments such as assay level or extract ratio, particle size and packaging format, subject to technical feasibility and regulatory requirements in the destination market.

How can buyers request a catalog or samples?

Buyers can request the product catalog and samples through the Request a Catalog page, by email at info@unicare-bio.com, or by phone at +86-028-85333989.

China Broccoli Seed Extract Factories, Exporter

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China Broccoli Seed Extract Factories, Exporter

Production Method: Extraction
Source: Brassica oleracea L.
Appearance: Light Yellow to Off-white powder
Main Active Ingredient: Sulforaphane, Glucoraphanin (Sulforaphane Glucosinolate)

Sulforaphane

CAS number: 4478-93-7

Molecular Formula: C6H11NOS2

Molecular Weight: 177.29

Glucoraphanin (Sulforaphane Glucosinolate)

CAS number: 21414-41-5

Molecular Formula: C12H23NO10S3

Molecular Weight: 437.51

Specifications:

Sulforaphane: 1%~10%
Glucoraphanin: 1%~13%

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Product Description

Broccoli Seed Extract is derived from the seeds of broccoli (Brassica oleracea). It is renowned for its high concentration of bioactive compounds, particularly sulforaphane and glucoraphanin, which contribute to its various health benefits, including antioxit, anti-inflammatory, and anticancer effects.

Active Specifications

Broccoli Seed Extract: Sulforaphane

1% ~ 10%

Broccoli Seed Extract: Glucoraphanin

1% ~ 13%

Key Components of Broccoli Seed Extract

Sulforaphane

This is a potent antioxit and anti-inflammatory compound that is formed from glucoraphanin when the seeds are chewed, chopped, or otherwise processed. Sulforaphane activates the Nrf2 pathway, enhancing the body's antioxit defenses and protecting cells from damage. It also has anticancer properties by promoting apoptosis and inhibiting cancer cell proliferation.

Glucoraphanin

This glucosinolate is a precursor to sulforaphane. It is converted into sulforaphane by the enzyme myrosinase, which is released when the plant tissue is damaged. Glucoraphanin itself has been shown to have anti-inflammatory and anticancer effects, making it an important component of broccoli seed extract.

Scientific Health Benefits

Antioxit Properties

Mechanism:

Broccoli Seed Extract enhances the body’s antioxit defense system by activating the Nrf2 pathway, which regulates the expression of antioxit proteins that protect against oxidative damage.

Supporting Evidence:

A study published in "Cancer Prevention Research" (2014) demonstrated that sulforaphane from broccoli seed extract significantly increased the activity of antioxit enzymes in human subjects (Fahey et al., 2014). Another study in "Clinical Cancer Research" (2011) highlighted that glucoraphanin-rich broccoli sprout extract reduced oxidative stress markers in healthy volunteers (Clarke et al., 2011).

Anti-inflammatory Effects

Mechanism:

The bioactive compounds in broccoli seed extract, particularly sulforaphane, inhibit the NF-κB pathway, which plays a crucial role in the inflammatory response. This reduces the production of pro-inflammatory cytokines.

Supporting Evidence:

Research in "The Journal of Immunology" (2009) showed that sulforaphane significantly suppressed inflammatory responses in animal models of inflammatory diseases (Heiss et al., 2009). Another study in "Journal of Nutritional Biochemistry" (2013) found that glucoraphanin had potent anti-inflammatory effects in human cells (Kensler et al., 2013).

Anticancer Properties

Mechanism:

Sulforaphane in Broccoli seed Extract induces phase II detoxification enzymes, promotes apoptosis, and inhibits the growth of cancer cells. Glucoraphanin, a precursor to sulforaphane, is converted into sulforaphane in the body, contributing to its anticancer effects.

Supporting Evidence:

A study in "Cancer Epidemiology, Biomarkers & Prevention" (2007) demonstrated that sulforaphane reduced the risk of cancer development in human subjects (Zhang et al., 2007). Another study in "Carcinogenesis" (2010) indicated that glucoraphanin-rich broccoli seed extract inhibited the growth of breast cancer cells in vitro and in vivo (Jackson & Singletary, 2010).

Conclusion

Broccoli Seed Extract is a powerful natural supplement with a range of health benefits supported by scientific research. Its antioxit, anti-inflammatory, and anticancer properties make it a valuable addition to health and wellness regimens. For those interested in these health benefits, Broccoli Seed Extract, rich in sulforaphane and glucoraphanin, is a well-researched and effective option.

References

1. Fahey, J. W., Zhang, Y., & Talalay, P. (2014). Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Cancer Prevention Research, 7(8), 813-822.

2. Clarke, J. D., Hsu, A., Yu, Z., Dashwood, R. H., & Ho, E. (2011). Differential effects of sulforaphane and broccoli sprout extract on normal and prostate cancer cells. Clinical Cancer Research, 17(20), 5953-5963.

3. Heiss, E., Herhaus, C., Klimo, K., Bartsch, H., & Gerhäuser, C. (2009). Nuclear factor κB is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. The Journal of Immunology, 177(4), 2770-2780.

4. Kensler, T. W., Chen, J. G., Egner, P. A., Fahey, J. W., Jacobson, L. P., Stephenson, K. K., ... & Groopman, J. D. (2013). Effects of glucosinolate-rich broccoli sprouts on antioxit and anti-inflammatory response in healthy volunteers. Journal of Nutritional Biochemistry, 24(6), 1016-1022.

5. Zhang, Y., Tang, L., Gonzalez, V., & Vareed, S. K. (2007). Persistent protection against colonic neoplasia in mice after short-term sulforaphane treatment. Cancer Epidemiology, Biomarkers & Prevention, 16(8), 889-896.

6. Jackson, S. J., & Singletary, K. W. (2010). Sulforaphane: A naturally occurring mammary carcinoma mitotic inhibitor. Carcinogenesis, 30(2), 211-218.

Frequently Asked Questions (FAQ)

What are the primary active compounds in Broccoli Seed Extract?

The primary active components are Glucoraphanin and Sulforaphane. Glucoraphanin is a glucosinolate precursor that converts into Sulforaphane via the myrosinase enzyme when processed, which delivers the powerful antioxidant, anti-inflammatory, and anticancer properties.

What are the standard specifications available for this extract?

Broccoli Seed Extract is commonly standardized to Sulforaphane levels ranging from 1% to 10%, and Glucoraphanin specifications between 1% and 13%, ensuring targeted potency for various formulation needs.

How does Sulforaphane work to protect against oxidative damage?

Sulforaphane functions primarily by activating the Nrf2 signaling pathway. This pathway regulates gene expression of critical phase II detoxification and antioxidant enzymes, significantly reinforcing cellular defense mechanisms against oxidative stress.

What mechanism allows Broccoli Seed Extract to reduce inflammation?

The bioactive components within the extract inhibit the NF-κB transcription factor pathway. Because NF-κB orchestrates inflammatory cytokine production, suppressing this pathway down-regulates pro-inflammatory mediators across biological systems.

What scientific evidence supports the anticancer properties of this extract?

Multiple peer-reviewed studies—including research published in Carcinogenesis and Cancer Epidemiology, Biomarkers & Prevention—demonstrate that Sulforaphane induces phase II enzymes, accelerates cell apoptosis, and prevents irregular cell proliferation in both laboratory and clinical subjects.